Multishot is one of the available upgrades to the player in Mr. Autofire, it allows the character to fire another volley of bullets at the cost of about 25% of the main damage, you can get only one bonus volley, because of the Multishot's ability to fire rapidly, it pairs well with every weapon, especially the Laser Rifle.
pairs well with:
Focus shots
any of the bullet count increase upgrades
any weapon
notes:
due to increasing the amount of bullets hit, this is an exceptionally efficient upgrade